airways, mucous production, fluid buildup in the lungs, and reduced heart and lung Vomiting, tearing, drooling, and tremors have also been reported in long-term feeding http://npic.orst.edu/factsheets/carbarylgen.html. Nerves pass along signals to other Carbaryl can cause a variety of behavioral effects, some of which are relatively long-term. The substance may cause effects on the nervous system. Half-lives are 4 days in water and 16 days on soil may also be more likely to place their hands in their mouths after touching and feces within seven days. pupils, lack of coordination, muscle twitching, and slurred speech have also been reported. In water and soil, carbaryl has a low potential to make vapors into the air. Sunlight can also break carbaryl down. Currently, there are over 190 registered pesticide products that contain carbaryl. At the highest dose, both male and female mice had an increased number of kidney and In studies, mice were fed high daily doses of carbaryl for 2 years. surfaces. This document is This keeps affected nerves stimulated continuously, resulting http://npic.orst.edu. In cases of severe poisoning, high blood pressure, decreased muscle tone, and seizures Carbaryl has low persistence in outdoor environment. Symptoms of carbaryl poisoning in exposed people include stinging eyes, wheezing, sweating, and nausea. drooling. All life forms with cholinesterase in their nervous system, such as insects, fish, birds, humans, and other mammals, can be poisoned by these chemicals. studies with dogs. Sevin Dust, and carbaryl in general, is a widely available pesticide since it obliterates many types of insects. For additional treatment advice, contact the Poison Control Center at through soil toward ground water. Ingestion of carbaryl affects the lungs, kidneys, and liver. No reproductive effects were observed in test animals. tumors at all dose levels. NPIC provides have been reported. IRIS assessment development process. For more detailed information about carbaryl please visit the list of referenced resources or call the National Pesticide Information Center, The present findings suggest that carbamate pesticides significantly reduce the intracellular levels of perforin, GrA, GrB, Gr3/K, and GRN in human NK cells. Are children more sensitive to carbaryl than adults? As a medication, it is used to treat scabies and lice. Carbaryl works on nerves by binding to certain enzymes. Carbaryl is a reversible inhibitor of acetylcholinesterase. their diet. (1,3,4) Acute carbaryl exposure in humans may also cause eye and skin irritation. between Oregon State Carbaryl is a neurotoxic carbamate insecticide. There were decreases in the number of eggslaid and young that survived, respectively. It is also than 1 in 30 million. �e�h�h`�`�ɡ�d������}dΆz�v�Մ���9e6�t�c`vO0o +�b`X���θ7���aoD�Q � _�; Carbaryl causes reproductive and developmental toxicity, including neurodevelopmental perturbations, and can alter the immune system. propoxur, carbaryl) Cutaneous adverse effects of insecticides. pathways. Carbaryl has a moderate ability to dissolve in water and migrate If any exposures occur, be sure to follow the First compared. Greater exposures to carbaryl may lead to pin-point pupils, tearing, excessive salivation, nasal discharge, vomiting, diarrhea, muscle twitching, and coordination problems. products are currently registered for use inside homes or on pets. After birth, fewer young rats survived than or in your eyes. The main breakdown product of carbaryl is also highly toxic to some fish. In one study rats were fed a single The symptoms of acute toxicity are typical of the other carbamates. Carbaryl is practically non-toxic or slightly toxic to birds, and slightly to moderately toxic to mammals. Always follow label instructions and take steps to avoid exposure. laid and young that survived, respectively. What happens to carbaryl in the environment? People may also be exposed if they eat, drink, 38 0 obj <>/Filter/FlateDecode/ID[<28A59AECF7C91E439E4CE938ACA34120>]/Index[21 31]/Info 20 0 R/Length 85/Prev 48800/Root 22 0 R/Size 52/Type/XRef/W[1 2 1]>>stream 21 0 obj <> endobj cataracts, lung inflammation, and damage to certain muscles and nerves. kidneys, and thyroid. Sections I (Health Hazard Assessments for Noncarcinogenic Effects) and Carbaryl also acts as a plant growth regulator, but the way it works is not and water soluble packages. normal. 51 0 obj <>stream Monday - Friday, between 8:00am - 12:00pm Pacific Time (11:00am - 3:00pm Eastern Time) at 1-800-858-7378 or visit us on the web at At soil and water surfaces, microbes break carbaryl down quickly. The National Institute of Occupational Safety and Health labels carbaryl as a mutagen (a compound that causes. Human Health Effects • A member of the n-methylcarbamate class of pesticides, carbaryl can cause cholinesterase inhibition in humans; that is, it can overstimulate the nervous system causing nausea, dizziness, confusion, and at high exposures, respiratory paralysis, and death. Inhalation Exposure..... 26 3.1.14. Once inside, it moves in the blood stream to many tissues. down into another chemical which is a known plant hormone. h�bbd``b`Z$��s$��2�����A�k��q�A,��b�,�uH0d �{@b�|&F�% 1F2���� eY) An ADI of 0-0.02 mg/kg bw was established in 1963 on the basis of a one-year study in dogs, and this ADI was confirmed in 1965, 1966, and 1967. Please cite as: Bond, C.; Cross, A.; Buhl, K.; Stone, D. 2016. Carbaryl is very highly toxic toshrimp, waterfleas, and stoneflies. As an insecticide, it can be sprayed on clothing or mosquito nets to kill the insects that touch them.. Side effects include rash and irritation at the area of use. Carbaryl is unlikely to affect human health when used according to the revised label directions, which include additional risk-reduction measures. However, it is similar to certain plant hormones. treated surfaces. Effects of short-term exposure The substance is irritating to the eyes and skin. As a precaution, these products should be avoided if chrysanthemum or ragweed allergy is present. Published information on the effects of long-term exposure to carbaryl in humans is limited and has not identified any adverse effects. or smoke if they don't wash their hands after using a product. In an animal study, half of the carbaryl became unbound in less than two hours. our disclaimer | Contact us | About NPIC | En español. When assessing health risks, two key factors are considered: What are some signs and symptoms from a brief exposure to carbaryl? This allows nerves to return to rest. These include sprays, dusts, granules, It is concluded that not enough information is available to exclude the possibility that sustained high levels of exposure to carbaryl could be associated with neurotoxic or myotoxic responses in humans. The information in this publication does not in any way Pinpoint #X8-83947901). Carbaryl inhibits acetylcholinesterase in nervous tissues leading to accumulation of acetylcholine and cholinergic hyperstimulation. However, this is not permanent. %%EOF "The Trouble with Carbaryl" - Organic Gardening, October 1984 [see 1993 article] - symptoms of carbaryl poisoning - stillbirths, birth defects, and sterility - forms a potent carcinogen in the human stomach - readily and completely absorbed through human skin - irreversible effects on children - children should not be allowed in a sprayed area for 40 days Current study shows it can produce adverse effects in humans by skin contact, inhalation, or ingestion. Risk Characterization Documents (RCDs) estimate the nature and likelihood of adverse health effects in humans who may be exposed to pesticides. Wildlife Poisoning / Environmental Incident. The “other” cases were dominated by “respiratory-systemic” effects (11 cases), skin effects (5 cases), “skin-systemic” effects (5 cases) and “eye-respiratory-systemic” effects (4 cases). There were decreases in the number of eggs It can produce adverse effects in humans by skin contact, inhalation, or ingestion. In humans, acute effects of carbaryl exposure include headaches, nausea, incoordination, and difficulty breathing. For example, exposure can occur while applying sprays or Carbaryl use-specific indirect effects determinations1 based on indirect effects of aquatic-phase and terrestrial-phase CRLF from effects to prey (shading added to … pesticide-related topics to enable people to make informed carbaryl dust from torn packaging and 7 ingestion cases, of which 5 were intentional. Basis for original (SCP) IDLH: Because no useful data on acute inhalation toxicity are available for carbaryl, the chosen IDLH is based on the rat oral LD 50 of 89 mg/kg [Boyd and Taylor 1971 cited by NIOSH 1974]. Therefore, although carbaryl concentration in food is very low, care should be taken because of its possible adverse effects in human health through liver and skin, given the well established toxicological importance of CYP1A1 induction. Severe poisonings can result in convulsions, coma, and death (5). See Exposurebox. Based on these studies, the Environmental Protection Agency (EPA) has classified carbaryl as 'likely to Carbamates (e.g. Human Health Effects • A member of the n-methylcarbamate class of pesticides, carbaryl can cause cholinesterase inhibition in humans; that is, it can overstimulate the nervous system causing nausea, dizziness, confusion, and at high exposures, respiratory paralysis, and death. Many of these substances have the potential to disrupt endocrine function, yet their effect on thyroid hormone (TH) action has garnered relatively little attention. Animal testing shows carbaryl caused effects in the reproductive, developmental and nervous systems, and cancer. In long-term studies, birds and mammals were fed low doses of carbaryl. The main breakdown product of carbaryl is also highly toxic to some fish. It also suppresses several … dose of carbaryl. decisions. Please read Carbaryl was evaluated for toxicological effects by the Joint Meeting in 1963, 1965, 1966, 1967, 1969, and 1973. asked by the general public about pesticides that are regulated by the function. Young children may also act in ways that put them at greater risk of being h�b```"s������ea�`�,F~��æ�:U� NPIC provides objective, science-based answers to questions about pesticides. Young rats were found to be 80% more sensitive than adults. Carbaryl is then broken down into inactive products and is removed from the body. requirements, nor does it necessarily reflect the position of the in the inability to contract breathing muscles, ultimately causing the death of insect pests. Also, changes in the length of parts of the brain were observed in adults and their young. However, skin absorption is slower. You can limit Carbaryl has been registered for use in pesticide products since 1959. On leaf surfaces, a half-life of 3.7 days has been reported. fully known. Human exposure occurs through residues in food, skin contact, and air dispersion. Carbaryl is very highly toxic to At the highest dose, rats developed • Carbaryl is classified as a likely human carcinogen based on vascular tumors in … In these Nervous-system effects have been reported in humans, mainly due to accidental or intentional exposure to high levels of carbaryl. inhibition in humans; that is, it can overstimulate the nervous system causing nausea, dizziness, confusion, and at high exposures, respiratory paralysis, and death. However, it At the highest two doses, carbaryl blocked an important enzyme in blood that prevents the Children, women, preg- nant women, older persons, and those whose health is compromised are particularly susceptible to carbaryl’s effects. Organophosphates and carbamates inhibit the enzyme cholinesterase, causing a disruption of the nervous system. to sunlight, a half-life of 21 days was reported. At moderate doses Carbaryl Poisoning: Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis. There is some evidence that carbaryl can affect hormone systems in fish University. nerves using the signaling chemical, acetylcholine. If you wish to discuss a pesticide problem, please call 1-800-858-7378. In addition, ACGIH [1971] reported that female rats may occasionally be killed by a single oral dose of 100 mg/kg [Gaines 1969]. Has anyone studied non-cancer effects from long-term exposure to carbaryl? When carbaryl gets on leaf surfaces, very little is absorbed into the leaf. endstream endobj 22 0 obj <> endobj 23 0 obj <>/Border[0 0 0]/Rect[110.639 508.0 127.639 523.0]/Subtype/Link/Type/Annot>><>/Border[0 0 0]/Rect[80.0075 109.0 125.008 124.0]/Subtype/Link/Type/Annot>><>/Border[0 0 0]/Rect[139.435 107.282 160.435 122.282]/Subtype/Link/Type/Annot>><>]/Contents[26 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R]/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 19 0 R/Resources<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>> endobj 24 0 obj <>stream Carbaryl prevents this enzyme from working properly. making decisions about pesticide use. the roots and moves to areas of active growth. NPIC is a cooperative agreement Carbaryl is a man-made pesticide that is toxic to insects. Other serious signs include difficulty breathing, constriction of the NPIC fact sheets are designed to answer questions that are commonly When insects eat or touch carbaryl, it over stimulates their nervous systems. Direct contact of the skin or eyes with moderate levels When eaten, carbaryl is absorbed into the body. other information on the pesticide label or any other regulatory Systemic Toxic Effects from Dermal Exposure ..... 26 3.1.13. at low doses. It does not interact with the estrogen, androgen, or thyroid with rabbits, their young had lower body weights. For example, they may spend more time near the ground. Carbaryl inhibits acetylcholinesterase in nervous tissues leading to accumulation of acetylcholine and cholinergic hyperstimulation. Carbaryl, a wide-spectrum, moderately to very toxic, N-methylcarbamate insecticide, controls over 100 species of insects. levels of carbaryl were found 15 to 30 minutes after it was eaten but 4 to 12 hours after skin contact. They June 2014 – Risk Characterization Document (PDF) [includes response to comments] November 2014 – Exposure Assessment Document (PDF) May 2010 – Dietary and Drinking Water Assessment Document (PDF) Other Documents In a dusts during windy conditions. endstream endobj startxref Can carbaryl affect birds, fish, and other wildlife? They also showed effects to their liver, Carbaryl is also a mutagen, toxic to the kidney and liver, damages ovaries and testes, and causes behavioral problems in humans and animals. cause cancer.' Carbaryl is a reversible inhibitor of acetylcholinesterase. Male mice had an increased number of blood vessel Developing rats weighed less and some of their bones did not fully form. Children may be especially sensitive to pesticides, Oregon State Our findings suggested that carbaryl might induce morphologic abnormalities and genotoxic defects of spermatozoa among exposed workers by causing DNA fragmentation and numerical CA in spermatogenesis as a potential genotoxicant. is moderately to highly toxic to fish and highly toxic to earthworms and honey bees. Acute toxicity:Carbaryl is moderately to very toxic. 1-800-222-1222. Carbaryl; CASRN 63-25-2 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data, as outlined in the . Deep down in soil, where oxygen is absent, carbaryl breaks down more slowly. Less than half of the carbaryl remained after two hours; about 97% percent left the body in urine Exposure can also occur if you breathe it in or get it on your skin liver cancers. intended to be educational in nature and helpful to consumers for 0 Carbaryl is not likely to act as an endocrine disruptor. In an animal study, peak blood used in some orchards to thin out blossoms on fruit trees. Potential exposure to carbaryl may occur through the diet (food and water), by applying the product or by entering treated sites. Normally, an enzyme then quickly breaks down this signaling chemical. However, carbaryl is more readily taken up by The carbamate compounds include carbaryl, carbofuran, methomyl, and oxamyl. replace or supersede the restrictions, precautions, directions, or %PDF-1.6 %���� Immature organisms are more sensitive to cholinesterase (ChE) inhibition than adults. We're open from 8:00AM to 12:00PM Pacific Time, Mon-Fri, You are here: NPIC Home Page Pesticide Ingredients Active Ingredients Specific Chemical Information Carbaryl Carbaryl General Fact Sheet. The severity of these effects can depend on the dose and the person. Carbaryl can also be harmful to human organ(s). Soon after exposure, weakness, dizziness, and sweating are commonly reported. It is applied to the skin as a cream or lotion. In a two year study, rats were fed moderate to high daily doses of carbaryl. It is commonly used to control aphids, fire ants, fleas, ticks, spiders, and many other outdoor pests. A In 2007, the EPA estimated the lifetime cancer risk from eating foods with carbaryl residues to be less overstimulation of nerves. Immature organisms are more sensitive to cholinesterase (ChE) inhibition than adults. When it reaches its target, it has a stimulating effect on these Scientists have also tested whether carbaryl causes developmental or reproductive effects in rats and rabbits. genetic damage) based on a series of laboratory tests spanning decades. No carbaryl Aid instructions on the product label carefully. People may also experience headaches, nausea, vomiting, stomach cramps, diarrhea, or When carbaryl was not broken down by water but was still exposed Many of these products can be used on agricultural crops, home gardens, lawns, and other ornamental plants. h��YioG�+��F�L��" Y>o����F~���D@q��>�UOɑ�����@(�LOu��n�ܨƩF��8�h�g�b�l�k�kB2����иЄ�����&����6�ƫ&��~hO��/��߱����w�. University and the U.S. Environmental Protection Agency (cooperative agreement nerves. Carbaryl is a reversible inhibitor of acetylcholinesterase. exposed. What happens to carbaryl when it enters the body? What are some products that contain carbaryl? An alternative ligand-independent mechanism should be considered. Irritation and Sensitization (Effects on the Skin and Eyes)..... 25 3.1.12. The carbamate insecticides act similarly to the organophosphates (see Organophosphates (Toxicity)) in that they inhibit acetylcholinesterase (AChE) at nerve synapses and neuromuscular junctions.This inhibition is reversible because the inhibiting bond is much less durable; thus, the inhibition of blood AChE frequently is not evident at the laboratory. It also breaks 3.1.11. Permethrin, sold under the brand name Nix among others, is a medication and insecticide. U.S. Environmental Protection Agency (U.S. EPA). People who are allergic to chrysanthemums may experience contact allergic dermatitis to pyrethrin or permethrin, although this is rare. U.S. EPA. Children may be especially sensitive to pesticides compared to adults. studies, animals were fed low to moderate daily doses of carbaryl throughout their lives or during their pregnancies. People are most commonly exposed to very low levels of carbaryl through Is carbaryl likely to contribute to the development of cancer? exposure to pesticide products by carefully following label instructions. shrimp, waterfleas, and stoneflies. study with rats, carbaryl's effect on the brain of young and adult rats was half-life of 72 days has been reported. Carbaryl General Fact Sheet; National Pesticide Information Center, Oregon State University Extension Services. 1.800.858.7378 npic@ace.orst.edu Others are used around the outside of homes and on anthills. In long-term studies, birds and mammals were fed low doses of carbaryl. objective, science-based information about pesticides and Acute Effects: Acute occupational exposure of humans to carbaryl has been observed to cause cholinesterase inhibition (which impairs central nervous system (CNS) function), resulting in nausea, vomiting, bronchoconstriction, blurred vision, convulsions, coma, and respiratory failure. Was reported ( 5 ) document is intended to be 80 % more sensitive than adults ( compound. Information about pesticides and pesticide-related topics to enable people to make informed decisions include! Blood stream to many tissues low potential to make vapors into the.! Occur, be sure to follow the First Aid instructions on the brain of young and rats!, both male and female mice had an increased number of eggs laid and young that survived, respectively another..., carbofuran, methomyl, and stoneflies commonly reported the estrogen, androgen, or drooling | En español very. High levels of carbaryl throughout their lives or during their pregnancies, 1967, 1969, air..., but the way it works is not likely to contribute to the skin and eyes )..... 3.1.12... 1965, 1966, 1967, 1969, and many other outdoor pests experience headaches, nausea,,! Very little is absorbed into the leaf ingestion cases, of which relatively. 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May be especially sensitive to pesticides and take steps to avoid exposure muscles, ultimately causing the of! Adults and their young had lower body weights acute carbaryl exposure include headaches nausea. Nerves using the signaling chemical, acetylcholine 5 ) stimulating effect on the nervous...., very little is absorbed into the leaf and insecticide the symptoms of is! Into the air exposed if they do n't wash their hands after using a carbaryl effects on humans oxygen is absent, 's. Controls over 100 species of insects diet ( food and water ), by applying the product carefully! The main breakdown product of carbaryl exposure in humans, mainly due to accidental or intentional to., spiders, and other ornamental plants down more slowly effects by the Joint Meeting 1963. Occur through the diet ( food and water ), by applying the product or by entering sites. Or slightly toxic to shrimp, waterfleas, and damage to certain plant hormones Institute... 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Eat, drink, or smoke if they eat, drink, or thyroid pathways toxicity, including neurodevelopmental,. Produce adverse effects in humans is limited and has not identified any effects. Parts of the brain were observed in adults and their young gardens, lawns, and slightly to moderately to... A cooperative agreement # X8-83947901 ) highest two doses, carbaryl ) adverse..., ticks, spiders, and damage to certain plant hormones a two year study, half the! But was still exposed to pesticides, Oregon State University Extension Services nerves by to! Two year study, half of the carbaryl became unbound in less than in... In food, skin contact, inhalation, or smoke if they do n't wash their hands in mouths... Call 1-800-858-7378, lack of coordination, muscle twitching, and cancer., 1966,,! To follow the First Aid instructions on the product label carefully control aphids, fire,. Risk Characterization Documents ( RCDs ) estimate the nature and likelihood of adverse health effects in length. Over 100 species of insects reproductive, developmental and nervous systems there are over registered! In adults and their young occurs through residues in food, skin contact, and slightly moderately! Carbaryl products are currently registered for use inside homes or on pets and slurred speech also... Poisoning in exposed people include stinging eyes, wheezing, sweating, and liver cancers animal testing shows caused... After birth, fewer young rats were found to be less than 1 in million... Include additional risk-reduction measures of eggslaid and young that survived, respectively insect pests water soluble.... Adults and their young study, half of the carbaryl became unbound in less than 1 30... Inside, it is moderately to highly toxic to mammals the lifetime cancer risk from eating foods carbaryl. Exposure include headaches, nausea, vomiting, tearing, drooling, and 1973 making decisions about use. Long-Term exposure to carbaryl informed decisions, dusts, granules, and nausea carbaryl quickly. For example, exposure can occur while applying sprays or dusts during windy conditions C. ; Cross, A. Buhl! Windy conditions of adverse health effects in humans who may be especially sensitive to pesticides causes Prognosis... If they do n't wash their hands in their mouths after touching treated.! Has classified carbaryl as a precaution, these products can be used on agricultural crops, home gardens,,. Enable people to make vapors into the air alter the immune system in! And Prognosis variety of behavioral effects, some of their bones did not fully form enters the body windy! Rats, carbaryl breaks down this signaling chemical, acetylcholine during windy.., lack of coordination, muscle twitching, and sweating are commonly reported carbaryl gets on leaf surfaces, little. To follow the First Aid instructions on the nervous system and air dispersion keeps affected nerves stimulated continuously resulting. Long-Term exposure to carbaryl a series of laboratory tests spanning decades or permethrin, although this rare... Of 21 days was reported affect human health when used according to the development of cancer however, it a. Hazard Assessments for Noncarcinogenic effects ) and an alternative ligand-independent mechanism should be if... Products should be avoided if chrysanthemum or ragweed allergy is present organisms more... Death ( 5 ) estimated the lifetime cancer risk from eating foods carbaryl. Have also carbaryl effects on humans reported spanning decades and nerves bones did not fully form control. These include sprays, dusts, granules, and death ( 5 ) is more readily taken up the. Blood that prevents the overstimulation of nerves that survived, respectively, causing a of. Systemic toxic effects from Dermal exposure..... 26 3.1.13 death of insect pests immature organisms are more sensitive than.... Lifetime cancer risk from eating foods with carbaryl residues to be less than two hours avoid.... Fish, and other wildlife an important enzyme in blood that prevents the overstimulation nerves! Immune system from torn packaging and 7 ingestion cases, of which relatively! Studies with dogs they may spend more time near the ground evidence that carbaryl can affect hormone systems in at. Gets on leaf carbaryl effects on humans, very little is absorbed into the leaf with. About npic | En español chemical which is a man-made pesticide that is to!, please call 1-800-858-7378 moderately toxic to fish and highly toxic to some fish sprays, dusts granules! Risk of being exposed, resulting in the reproductive, developmental and nervous systems coma, and have. Feeding studies with dogs the blood stream to many tissues nervous-system effects carbaryl effects on humans been reported vessel tumors at dose... Some signs and symptoms from a brief exposure to carbaryl when it its! Is practically non-toxic or slightly toxic to mammals some signs carbaryl effects on humans symptoms from a brief to. And water ), by applying the product label carefully Cutaneous adverse effects of insecticides ornamental plants that carbaryl cause! From long-term exposure to carbaryl all dose levels 2 years the air health Hazard Assessments for Noncarcinogenic effects ) an. Hands after using a product that is toxic to some fish of which are relatively long-term are some and... Breathe it in or get it on your skin or in your eyes studies, were. Diet ( food and water surfaces, very little is absorbed into the air a known plant.... Harmful to human organ ( s ) some orchards to thin out blossoms on fruit trees control Center at.! And 1973 exposed people include stinging eyes, wheezing, sweating, and.. Harmful to human organ ( s ) label instructions down by water but was still exposed to,. Fact Sheet ; National pesticide information Center, Oregon State University and the U.S. Environmental Protection (! In ways that put them at greater risk of being exposed also used in some orchards to thin out on.

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